Tetrahedron p. 7459 - 7468 (1989)
Update date:2022-09-26
Topics:
Baldwin, Jack E.
Miranda, Tania
Moloney, Mark
Hokelek, Tuncer
Deprotonation of protected pyroglutamates 1(c), 1(d), and 1(e) with lithium di-isopropylamine (LDA) or lithium hexamethyldisilazide (LiHDMS) in THF, followed by reaction with electrophiles, leads to the formation of 4-substituted pyroglutamates in good yield.This approach has been used for the synthesis of the novel amino acid (4).Key Words: pyroglutamic acid; chiral amino acid synthesis
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