Asymmetric Synthesis of 4,4-Disubstituted 1-Naphthalenones. Diastereoselectivity as a Function of Metal Oxides

DOI: 10.1021/jo00301a002

Source and publish data:

Journal of Organic Chemistry p. 4233 - 4235 (1990)

Update date:2022-07-29

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Authors:

Wuensch, Thomas

Meyers, A. I.

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Article abstract of DOI:10.1021/jo00301a002

Chiral tricyclic lactam (5) was sequentionally metalated (LDA or LDA/zirconocene halides) and alkylated to give quaternary alkylation products (8) in 6-54:1 diastereomeric ratio.Reduction and hydrolysis furnish the title compound in three steps with >99 p

Full text of DOI:10.1021/jo00301a002

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