Synthesis and antimycobacterial properties of N-substituted 6-amino-5-cyanopyrazine-2-carboxamides

DOI: 10.1016/j.bmc.2010.12.054

Source and publish data:

Bioorganic and Medicinal Chemistry p. 1471 - 1476 (2011)

Update date:2022-08-02

Topics: Synthesis Column chromatography Yield NMR spectroscopy Bioassay Recrystallization Mass spectrometry (MS) Solubility Pyrazine Minimum inhibitory concentration (MIC) In vitro Testing Structure-Activity Relationship (SAR) Mycobacterium tuberculosis Heterocyclic compound N-Substituted Antimycobacterial Carboxamide MIC90

Authors:

Zitko, Jan

Dolezal, Martin

Svobodova, Michaela

Vejsova, Marcela

Kunes, Jiri

Kucera, Radim

Jilek, Petr

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Article abstract of DOI:10.1016/j.bmc.2010.12.054

A series of fifteen new compounds related to pyrazinamide (PZA) were synthesized, characterized with analytical data and screened for antimycobacterial, antifungal and antibacterial activity. The series consists of 6-chloro-5-cyanopyrazine-2-carboxamide a

Full text of DOI:10.1016/j.bmc.2010.12.054

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