Journal of Organic Chemistry p. 1038 - 1047 (1993)
Update date:2022-08-03
Topics:
Crimmins, Michael T.
Nantermet, Philippe G.
Trotter, B. Wesley
Vallin, Isabelle M.
Watson, Paul S.
et al.
The copper-catalyzed conjugate addition-cycloacylation reaction of zinc homoenolates with acetylenic esters or acetylenic amides is described.The zinc homoenolate is prepared from <(ethoxycyclopropyl)oxy>trimethylsilane and zinc chloride in ether.Addition of an acetylenic amide or ester provides 2-carboxamido- or 2-carboalkoxy-3-alkylcyclopent-2-en-1-ones in good to excellent yields.The reaction can be carried out in the presence of a variety of sensitive functional groups including epoxides, α,β-unsaturated esters, acetals, silyl ethers, and furans.
View Morewebsite:http://www.angchenchem.com
Contact:+86-510-88302099 82327577
Address:Rm. 404/405, Floor 4th, No. 983 FengXiang Road, Wuxi, China
Xi'an caijing Opto-Electrical Science & Technology Co., LTD
Contact:+86-29-88294447
Address:NO.168 Zhangba Rd. East, Xi'an, P.R.China
Hangzhou Share Chemical Co., Ltd(expird)
Contact:+86-57187093700
Address:Hang Xing Road
Hangzhou Hysen Pharma co.,Ltd.
website:http://www.hysenpharma.cn/
Contact:0086-571-88298791
Address:#701,Gudun Road Hangzhou
Hebei Tianxiang Biological & Pharmaceutical Co., Ltd
Contact:86-0312-6615158
Address:No 42 fazhan street qingyuan county
Doi:10.1021/ol200429a
(2011)Doi:10.1021/jo00018a017
(1991)Doi:10.1039/P19810000218
(1981)Doi:10.1016/S0040-4020(01)91210-4
(1992)Doi:10.1002/anie.201006879
(2011)Doi:10.1021/ja0042027
(2001)
