Journal of Organic Chemistry p. 1038 - 1047 (1993)
Update date:2022-08-03
Topics:
Crimmins, Michael T.
Nantermet, Philippe G.
Trotter, B. Wesley
Vallin, Isabelle M.
Watson, Paul S.
et al.
The copper-catalyzed conjugate addition-cycloacylation reaction of zinc homoenolates with acetylenic esters or acetylenic amides is described.The zinc homoenolate is prepared from <(ethoxycyclopropyl)oxy>trimethylsilane and zinc chloride in ether.Addition of an acetylenic amide or ester provides 2-carboxamido- or 2-carboalkoxy-3-alkylcyclopent-2-en-1-ones in good to excellent yields.The reaction can be carried out in the presence of a variety of sensitive functional groups including epoxides, α,β-unsaturated esters, acetals, silyl ethers, and furans.
View MoreLaohekou Jinghong Chemical Co.,Ltd
Contact:+86-0710-3702747
Address:163.East，Huagong Road，Laohekou
Shaanxi HuaTai Bio-fine chemical company Ltd
Contact:86-029-87862197
Address:No. 5, 3rd Floor, 29 Yanta North Road, Beilin Dist.
Zhengzhou Minzhong Pharmaceutical Co.,ltd
Contact:0086-371-65797115
Address:15/F,Jiangshan Bldg, NO.126 Huanghe Road,Zhengzhou, China
Contact:0086-27-83607103/83642615
Address:No.498, Jianshe Ave, Wuhan, China
Shanghai Massive Chemical Technology Co., Ltd.
website:http://www.massivechem.com/
Contact:+86 21 34943721
Address:Room 435, 4th floor, Building 9, No. 2568 Gudai Road,Minhang District, Shanghai,
Doi:10.1021/ol200429a
(2011)Doi:10.1021/jo00018a017
(1991)Doi:10.1039/P19810000218
(1981)Doi:10.1016/S0040-4020(01)91210-4
(1992)Doi:10.1002/anie.201006879
(2011)Doi:10.1021/ja0042027
(2001)
