Stereoselective synthesis of MLN4924, an inhibitor of NEDD8-activating enzyme

DOI: 10.1021/jo2001897

Source and publish data:

Journal of Organic Chemistry p. 3557 - 3561 (2011)

Update date:2022-07-30

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Authors:

Lee, Hyuk Woo

Nam, Soo Kyung

Choi, Won Jun

Kim, Hea Ok

Jeong, Lak Shin

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Article abstract of DOI:10.1021/jo2001897

MLN4924 (1), which is in clinical trials as an anticancer agent, was stereoselectively synthesized from d-ribose via a route involving stereoselective reduction, regioselective cleavage of an isopropylidene moiety, and selective displacement of a cyclic s

Full text of DOI:10.1021/jo2001897

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