4-Substituted thiophene- and furan-2-sulfonamides as topical carbonic anhydrase inhibitors

DOI: 10.1021/jm00099a010

Source and publish data:

Journal of Medicinal Chemistry p. 3822 - 3831 (1992)

Update date:2022-08-02

Topics:

Authors:

Hartman Hartman

Halczenko

Smith Smith

Sugrue Sugrue

Mallorga

Michelson

Randall Randall

Schwam Schwam

Sondey Sondey

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Article abstract of DOI:10.1021/jm00099a010

A series of 4-substituted thiophene- and furan-2-sulfonamides was prepared and was found to possess nanomolar-level potency for inhibition of human carbonic anhydrase II in vitro. Selected examples from this group were further evaluated for their potentia

Full text of DOI:10.1021/jm00099a010

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