Substrate Leaving Group Control of the Enantioselectivity in the Palladium-Catalyzed Asymmetric Allylic Substitution of 4-Alkyl-1-vinylcyclohexyl Derivatives

Article abstract of DOI:10.1021/jo00303a016

The strong influence of the nature of the leaving group in allylic derivatives in their enantioselective Pd-catalyzed substitution by nucleophile is reported.Analysis of the stereochemical course of the Pd-catalyzed substitution of achiral trans-4-tert-bu