REACTION OF 2-AMINO-5-R-PHENYL-1,3,4-THIADIAZOLES WITH UNSATURATED ACIDS AND ACID CHLORIDES

DOI: 10.1007/BF00499422

Source and publish data:

Chemistry of Heterocyclic Compounds p. 228 - 231 (1990)

Update date:2022-08-05

Topics: IR spectroscopy Acylation Yield Catalyst Solvent reflux Nucleophilic substitution TLC (thin-layer chromatography) NMR (nuclear magnetic resonance) Michael addition Purification Condensation Reaction Reaction Mechanism Electrophilic Aromatic Substitution (EAS) Stoichiometry Acid chlorides Byproduct Unsaturated acids

Authors:

Zubets, I. V.

Vergizov, S. N.

Viktorovskii, I. V.

V'yunov, K. A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1007/BF00499422

Reaction of 2-amino-5-R-phenyl-1,3,4-thiadiazoles with unsaturated acids and acid chlorides in the presence of triethylamine takes place exclusively at the amino group to form 2-carboxyalkyl- and 2-acylamino-derivatives, respectively.

Full text of DOI:10.1007/BF00499422

Products guided by the article

Product name:3-[5-(4-Bromo-phenyl)-[1,3,4]thiadiazol-2-ylamino]-2-methyl-propionic acid

Cas No:128627-70-3

R&D Labs maybe for 128627-70-3

Winchem Industrial Co. Ltd.(expird)

Contact:86-574-83851061 86-574-87083208

Address:Room 905, No.3 Building,East Business Center, 456 Xingning Road, Ningbo City,China
Tengzhou Runlong Fragrance Co., Ltd.

website:http://www.tzrunlong.com/

Contact:--

Address:No. 78, Fushan Road, Biomedical Industrial Park, Dawu Town, Tengzhou, Shandong, 277514 China
xujianqiang

Contact:86-21-57725962

Address:shanghai
Henan Yellow River New Material Technology Co.Ltd.

website:http://www.yellowriverchem.com

Contact:0086-373-7278760

Address:Chengguan Town, Yuanyang County
Nanjing Legend Pharmaceutical & Chemical Co., Ltd.

Contact:+86-25-83767696

Address:14-7 Zhongshan Lu Guluo District, Nanjing

Relevant to this article

Guilty as charged: Non-innocent behavior by a pincer ligand featuring a central cationic phosphenium donor

Doi:10.1039/c0cc05739h
(2011)
Evaluation of Amide Bioisosteres Leading to 1,2,3-Triazole Containing Compounds as GPR88 Agonists: Design, Synthesis, and Structure-Activity Relationship Studies

Doi:10.1021/acs.jmedchem.1c01075
(2021)
Fourfold Suzuki-Miyaura and Sonogashira cross-coupling reactions on tetrahedral methane and adamantane derivatives

Doi:10.1002/ejoc.201001567
(2011)
Tunable poly(hydroxyl urethane) from CO₂-Based intermediates using thiol-ene chemistry

Doi:10.1002/pola.24631
(2011)
Optimisation, scope and limitations of enantioselective aldol reactions of an S-ketene silyl acetal with aliphatic aldehydes under (R)-BINOL-titanium(IV) catalysis conditions

Doi:10.1002/1099-0690(200210)2002:20<3419::AID-EJOC3419>3.0.CO;2-F
(2002)
Antirhinovirus structure-activity relationships of 6-substituted-9-(4-methylbenzyl)-2-trifluoromethyl-9H-purines

Doi:10.1016/0223-5234(90)90021-T
(1990)

Article Doi