REACTION OF 2-AMINO-5-R-PHENYL-1,3,4-THIADIAZOLES WITH UNSATURATED ACIDS AND ACID CHLORIDES

DOI: 10.1007/BF00499422

Source and publish data:

Chemistry of Heterocyclic Compounds p. 228 - 231 (1990)

Update date:2022-08-05

Topics: IR spectroscopy Acylation Yield Catalyst Solvent reflux Nucleophilic substitution TLC (thin-layer chromatography) NMR (nuclear magnetic resonance) Michael addition Purification Condensation Reaction Reaction Mechanism Electrophilic Aromatic Substitution (EAS) Stoichiometry Acid chlorides Byproduct Unsaturated acids

Authors:

Zubets, I. V.

Vergizov, S. N.

Viktorovskii, I. V.

V'yunov, K. A.

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Article abstract of DOI:10.1007/BF00499422

Reaction of 2-amino-5-R-phenyl-1,3,4-thiadiazoles with unsaturated acids and acid chlorides in the presence of triethylamine takes place exclusively at the amino group to form 2-carboxyalkyl- and 2-acylamino-derivatives, respectively.

Full text of DOI:10.1007/BF00499422

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