Chemistry of Heterocyclic Compounds p. 228 - 231 (1990)
Update date:2022-08-05
Topics: IR spectroscopy Acylation Yield Catalyst Solvent reflux Nucleophilic substitution TLC (thin-layer chromatography) NMR (nuclear magnetic resonance) Michael addition Purification Condensation Reaction Reaction Mechanism Electrophilic Aromatic Substitution (EAS) Stoichiometry Acid chlorides Byproduct Unsaturated acids
Zubets, I. V.
Vergizov, S. N.
Viktorovskii, I. V.
V'yunov, K. A.
Reaction of 2-amino-5-R-phenyl-1,3,4-thiadiazoles with unsaturated acids and acid chlorides in the presence of triethylamine takes place exclusively at the amino group to form 2-carboxyalkyl- and 2-acylamino-derivatives, respectively.
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Doi:10.1039/c0cc05739h
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(1990)
