PREPARATION, REACTIVITY, AND NEUROTOXICITY OF TRYPTAMINE-4,5-DIONE

DOI: 10.1016/S0040-4039(00)94405-8

Source and publish data:

Tetrahedron Letters p. 969 - 972 (1990)

Update date:2022-08-05

Topics:

Authors:

Cai, Ping

Snyder, John K.

Chen, Jin-Chung

Fine, Richard

Volicer, Ladislav

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Article abstract of DOI:10.1016/S0040-4039(00)94405-8

Tryptamine-4,5-dione protected as the carbamate was pepared in excellent overall yield by the oxidation of serotonin carbamate with benzeneseleninic anhydride.This o-quinone, which was potently neurotoxic, readily added sulfur nucleophiles under basic conditions including cysteine and glutathione in 1,4-fashion, a reactivity pattern which may reflect the mechanism of the neurotoxicity.

Full text of DOI:10.1016/S0040-4039(00)94405-8

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