Synthesis and Characterization of Nucleoside Peptides: Toward Chemical Ribonucleases. 1

Article abstract of DOI:10.1021/jo00304a026

Site-selective cleavage of nucleic acids by chemical analogues of nuclease enzymes is an area of major interest.Since imidazole is known to catalyze the hydrolysis of RNA, we postulated that oligonucleotides with pendant imidazole groups could be used to