Synthesis p. 253 - 255 (1990)
Update date:2022-08-02
Topics:
Venkov, Atanas P.
Vodenicharov, Daniel M.
1,2,3,4-Tetrahydro-2-methyl-4-phenylisoquinolines 6 are obtained from aromatic aldehydes 1, methyl amine and α-haloacetophenones 2 in the presence of sodium borohydride followed by cyclization with sulfuric acid and zinc in methanol.
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