Convenient Synthesis of Oligoribonucleotides Having 2'-5' and/or 3'-5' Phosphodiester Linkage

DOI: 10.1246/cl.1990.959

Source and publish data:

Chemistry Letters p. 959 - 962 (1990)

Update date:2022-09-26

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Authors:

Ozaki, Hiroaki

Nakamoto, Akio

Shimidzu, Takeo

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Article abstract of DOI:10.1246/cl.1990.959

Sequence-defined oligoribonucleosides having 2'-5' and/or 3'-5' phosphodiester linkage have been synthesized by use of 5'-protected ribonucleoside 2',3'-cyclic phosphoramidite on solid support.In coupling reaction, pKa of azole as a catalyst governs the activation.The resulting 2'-5' and/or 3'-5' linked oligoribonucleotides were easily separated by reversed-phase chromatography.

Full text of DOI:10.1246/cl.1990.959

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