Direct C-Glycosylation of Guanine Analogues: The Synthesis and Antiviral Activity of Certain 7- and 9-Deazaguanine C-Nucleosides

DOI: 10.1021/jm00172a011

Source and publish data:

Journal of Medicinal Chemistry p. 2750 - 2755 (1990)

Update date:2022-09-26

Topics:

Authors:

Girgis, Nabih S.

Michael, Maged A.

Smee, Donald F.

Alaghamandan, Hassan A.

Robins, Roland K.

Cottam, Howard B.

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Article abstract of DOI:10.1021/jm00172a011

C-Glycosylation of two guanine analogues, 9-deaza- and 7-deazaguanine, has been achieved under Friedel-Crafts conditions, providing a direct synthetic route to 9-deazaguanosine (4; 2-amino-7-β-D-ribofuranosyl-5H-pyrrolo<3,2-d>pyrimidin-4(3H)-one) and 8-β-

Full text of DOI:10.1021/jm00172a011

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