A Convenient and Versatile Synthesis of Chiral Aliphatic and Allylic Amines

DOI: 10.1055/s-1990-26900

Source and publish data:

Synthesis p. 453 - 454 (1990)

Update date:2022-09-26

Topics:

Authors:

Saari, Walfred S.

Fisher, Thorsten E.

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Article abstract of DOI:10.1055/s-1990-26900

Preparation of optically pure aliphatic and allylic amines from amino acids is described.Wittig olefination of α-Boc-amino aldehydes affords Boc-prodected allylic amines which can be deprotected to the corresponding chiral unsaturated amines.Catalytic reduction of the Wittig product prior to deprotection affords aliphatic amines of high optical purity.

Full text of DOI:10.1055/s-1990-26900

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