BAKER'S YEAST CATALYZED ASYMMETRIC CYCLOADDITION OF NITRILEOXIDES TO C=C BOND : IMPROVED CHIRAL RECOGNITION BY USING β-CYCLODEXTRIN

Article abstract of DOI:10.1016/S0040-4039(00)94732-4

Baker's yeast catalyzes for the first time the asymmetric cycloaddition reaction of arylsubstituted nitrileoxides 1 to vinylpyridines 2 to yield optically active 2-isoxazolines 3.The stereoselectivity is enhanced by fixing the geometry of both dipole and dipolarophile by using β-cyclodextrin as an additional binding cavity along with Baker's yeast.