Functional derivatives of 1-methyl 2-formyl 5-nitroimidazole. Evaluation of their antiparasitic activities

DOI: 10.1016/0223-5234(90)90115-J

Source and publish data:

European Journal of Medicinal Chemistry p. 321 - 325 (1990)

Update date:2022-08-05

Topics:

Authors:

Vanelle Vanelle

Maldonado

Jentzer Jentzer

Crozet Crozet

Savornin

Delmas Delmas

Gasquet Gasquet

Timon-David

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Article abstract of DOI:10.1016/0223-5234(90)90115-J

New imidazole compounds with pharmacological activity were obtained after subjecting 1-methyl-2-formyl-5-nitroimidazole to classical organic reactions: aldimine production, Knoevenagel reaction, and 4-ylidenebutenolide production. Some of these compounds exhibit significant antiparasitic activities against amoebae, trichomonas and leishmania.

Full text of DOI:10.1016/0223-5234(90)90115-J

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