Functional derivatives of 1-methyl 2-formyl 5-nitroimidazole. Evaluation of their antiparasitic activities

DOI: 10.1016/0223-5234(90)90115-J

Source and publish data:

European Journal of Medicinal Chemistry p. 321 - 325 (1990)

Update date:2022-08-05

Topics:

Authors:

Vanelle Vanelle

Maldonado

Jentzer Jentzer

Crozet Crozet

Savornin

Delmas Delmas

Gasquet Gasquet

Timon-David

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0223-5234(90)90115-J

New imidazole compounds with pharmacological activity were obtained after subjecting 1-methyl-2-formyl-5-nitroimidazole to classical organic reactions: aldimine production, Knoevenagel reaction, and 4-ylidenebutenolide production. Some of these compounds exhibit significant antiparasitic activities against amoebae, trichomonas and leishmania.

Full text of DOI:10.1016/0223-5234(90)90115-J

Products guided by the article

Product name:methyl-1 <(butene-2 olide-4 yl-4)-1 hydroxy-1 methyl>-2 nitro-5 imidazole

Cas No:129661-62-7

R&D Labs maybe for 129661-62-7

SNC | GOOD FORTUNE

Contact:0086-22-2822 1962 / 2822 1963

Address:B-808, No. 1, North-South Street, Hexi District,
Henan zhongda Biological Engineering Co., Ltd

Contact:86-28-18109029985

Address:shenzhou road,xuedian industrial estate,zhengzhou city,henan province CHN
Hunan Haili Chemical Industry Co.,Ltd.

Contact:+86-731-85521860

Address:No.251, 2nd Section, Furong Road, Changsha,Hunan,China
Shenyang Xingzhenghe Chemical Co., Ltd.

Contact:024-23509232

Address:No. 33, Naner Road, Heping Dist.
Zhejiang Newfine Industry Co.,Ltd.

Contact:+86-573-82262042

Address:No.225,Dongqing Road, garoms@163.com

Relevant to this article

Synthesis and Crystal Structures of the Dimetal Compounds 4-C4Me4)(η⁵-C2B9H11)>, 5-C2B9H11)>, and 5-C2B9H10)(CO)3(PPh3)2>

Doi:10.1039/DT9900001747
(1990)
Dehydrogenative silation, isomerization and the control of syn- vs. anti-addition in the hydrosilation of alkynes

Doi:10.1016/0022-328X(93)80236-5
(1993)
Phosphate tether-mediated approach to the formal total synthesis of (-)-salicylihalamides A and B

Doi:10.1021/jo200337v
(2011)
Palladium-catalyzed: C -glycosylation and annulation of o -alkynylanilines with 1-iodoglycals: Convenient access to 3-indolyl- C -glycosides

Doi:10.1039/d0ob01812k
(2020)
A new and mild access to N-functionalized formamido and thioformamido compounds using hypervalent silicon hydrides

Doi:10.1016/0040-4039(90)80131-5
(1990)
Copper-Catalyzed Asymmetric Annulation Reactions of Carbenes with 2-Iminyl- or 2-Acyl-Substituted Phenols: Convenient Access to Enantioenriched 2,3-Dihydrobenzofurans

Doi:10.1002/anie.201907943
(2019)

Article Doi