Reactivity of (3-chloro-2-methylenecycloalkyl)pallladium chloride dimers: A palladium mediated ring homologation--functionalization approach to the AR-7-7 skeleton of colchicine

Article abstract of DOI:10.1016/S0040-4020(01)82008-1

A palladium mediated ring homologation-functionalization approach to the Ar-7-7 tricyclic skeleton of colchicine from 1-arylcyclohexenes is described. This methodology involves the chloropalladation of 1-aryl-7-methylenebicyclo[4.1.0]heptanes to afford ar