Synthesis and biological activity of CCK peptides with antagonist activity for CCK-A-receptor

DOI: 10.1016/0223-5234(92)90028-Y

Source and publish data:

European Journal of Medicinal Chemistry p. 955 - 959 (1992)

Update date:2022-07-30

Topics: Synthesis Biological Activity Antagonist activity

Authors:

Boomgaarden

Henklein

Morgenstern

Sohr Sohr

Ott Ott

Martinez

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Article abstract of DOI:10.1016/0223-5234(92)90028-Y

The synthesis of a series of cholecystokinin analogues derived from the well-known antagonist Ge 410 (Suc-Tyr(SO₃)-Met-Gly-Trp-Met-Asp-β-phenethylamide) is reported. Replacements of L-Trp by D-Trp, Asp by Glu and Met by Nle were carried out and

Full text of DOI:10.1016/0223-5234(92)90028-Y

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