Synthesis and biological activity of CCK peptides with antagonist activity for CCK-A-receptor

Article abstract of DOI:10.1016/0223-5234(92)90028-Y

The synthesis of a series of cholecystokinin analogues derived from the well-known antagonist Ge 410 (Suc-Tyr(SO₃)-Met-Gly-Trp-Met-Asp-β-phenethylamide) is reported. Replacements of L-Trp by D-Trp, Asp by Glu and Met by Nle were carried out and