Synthesis of dinucleoside and dinucleotide phosphorodithioates via a phosphotriester approach

Article abstract of DOI:10.1016/S0040-4039(00)88887-5

5′ -O-Dimethoxytrityl and S-protected thymidine-3′ -phosphorodithioate, 3′ -O-acetylthymidine or thymidine-3′ -O-[β-cyanoethyl-(S-2,4-dichlorobenzyl)]-phosphorodithioate, 1-methylimidazole, and 2,4,6-triisopropylbenzenesulfonylchloride react to give excel