Palladium Catalysis in Cephalosporin Chemistry: General Methodology for the Synthesis of Cephem Side Chains

DOI: 10.1021/jo00310a014

Source and publish data:

Journal of Organic Chemistry p. 5833 - 5847 (1990)

Update date:2022-09-26

Topics:

Authors:

Farina, Vittorio

Baker, Stephen R.

Benigni, Daniel A.

Hauck, Sheila I.

Sapino, Chester

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Article abstract of DOI:10.1021/jo00310a014

We describe in full the palladium-catalyzed coupling of 3-(triflyloxy)cephems with organotin compounds, leading to the synthesis of 3-alkenyl-, 3-alkynyl-, and 3-arylcephems under exceptionally mild conditions.While this approach was not satisfactory for

Full text of DOI:10.1021/jo00310a014

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