Synthesis and Antiarrhythmic Activity of cis-2,6-Dimethyl-α,α-diaryl-1-piperidinebutanols

DOI: 10.1021/jm00105a003

Source and publish data:

Journal of Medicinal Chemistry p. 12 - 19 (1991)

Update date:2022-07-29

Topics:

Authors:

Hoefle, M. L.

Blouin, L. T.

Fleming, R. W.

Hastings, S.

Hinkley, J. M.

et al. et al.

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Article abstract of DOI:10.1021/jm00105a003

A series of α,α-diaryl-1-piperidinebutanols was evaluated for antiarrhythmic activity in the coronary ligated dog model.Structure-activity relationship studies indicated that the 2,6-dimethylpiperidine group yielded compounds with the best antiarrhythmic

Full text of DOI:10.1021/jm00105a003

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