Nonpeptide Renin Inhibitors Employing a Novel 3-Aza(or oxa)-2,4-dialkyl Glutaric Acid Moiety as a P2/P3 Amide Bond Replacement

DOI: 10.1021/jm00088a006

Source and publish data:

Journal of Medicinal Chemistry p. 1722 - 1734 (1992)

Update date:2022-09-26

Topics:

Authors:

Baker, William R.

Fung, Anthony K. L.

Kleinert, Hollis D.

Stein, Herman H.

Plattner, Jacob J.

et al. et al.

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Article abstract of DOI:10.1021/jm00088a006

A new series of renin inhibitors has been developed.The inhibitors feature a novel replacement for the P2/P3 dipeptide moiety normally associated with renin inhibitors.The dipeptide replacement was a (2S,4S)-3-aza(or oxa)-2,4-dialkylglutaric acid amide.Ex

Full text of DOI:10.1021/jm00088a006

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