CONJUGATE REDUCTION OF POLYFUNCTIONAL α,β-UNSATURATED CARBONYL COMPOUNDS USING 6. COMPATIBILITY WITH HALOGEN, SULFONATE, AND SULFUR SUBSTITUENTS

DOI: 10.1016/S0040-4039(00)89032-2

Source and publish data:

Tetrahedron Letters p. 3237 - 3240 (1990)

Update date:2022-08-04

Topics:

Authors:

Koenig, Thomas M.

Daeuble, John F.

Brestensky, Donna M.

Stryker, Jeffrey M.

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Article abstract of DOI:10.1016/S0040-4039(00)89032-2

In contrast to organocuprate conjugate addition and standard methods for conjugate reduction, use of the stable copper(I) hydride cluster, <(Ph3P)CuH>6, allows chemoselective conjugate reduction of α,β-unsaturated carbonyl compounds substituted at the γ-position with leaving groups.In addition, the compatibility of the conjugate reduction with organic halides and sulfonate groups is demonstrated.

Full text of DOI:10.1016/S0040-4039(00)89032-2

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