CONJUGATE REDUCTION OF POLYFUNCTIONAL α,β-UNSATURATED CARBONYL COMPOUNDS USING 6. COMPATIBILITY WITH HALOGEN, SULFONATE, AND SULFUR SUBSTITUENTS

Article abstract of DOI:10.1016/S0040-4039(00)89032-2

In contrast to organocuprate conjugate addition and standard methods for conjugate reduction, use of the stable copper(I) hydride cluster, <(Ph3P)CuH>6, allows chemoselective conjugate reduction of α,β-unsaturated carbonyl compounds substituted at the γ-position with leaving groups.In addition, the compatibility of the conjugate reduction with organic halides and sulfonate groups is demonstrated.