STEREOKONVERGENT SYNTHESIS OF A POTENT MOSQUITO LARVICIDE : (2E,4E,8E,10Z)-N-(2-METHYL PROPYL)-2,4,8,10-DODECATETRAENEAMIDE

Article abstract of DOI:10.1016/S0040-4020(01)87765-6

First total synthesis of (2E,4E,8E,10Z)-N-(2-methyl propyl)-2,4,8,10-dodecatetraene amide (1), by the condensation of (4E,6Z)-octadienyl phenyl sulfone (2) and ethyl-4-oxobutanoate (3) followed by double elimination reaction, which involves easily accessible reagents and simple transformations is described.