Bioorganic and Medicinal Chemistry Letters p. 2991 - 2997 (2011)
Update date:2022-07-29
Topics:
Unitt, John
Fagura, Malbinder
Phillips, Tim
King, Sarah
Perry, Matthew
Morley, Andrew
MacDonald, Cathy
Weaver, Richard
Christie, Jadeen
Barber, Simon
Mohammed, Rukhsana
Paul, Melanie
Cook, Andrew
Baxter, Andrew
The identification of two novel series of formyl peptide receptor 1 (FPR1) antagonists are reported, represented by methionine benzimidazole 6 and diamide 7. Both series specifically inhibited the binding of labelled fMLF to hrFPR1 and selectively antagonized FPR1 function in human neutrophils, making them useful in vitro validation tools for the target.
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Doi:10.1021/ja204016e
(2011)Doi:10.1016/j.tetlet.2011.04.008
(2011)Doi:10.1016/j.ica.2011.04.029
(2011)Doi:10.1039/c1cc11211b
(2011)Doi:10.1002/cmdc.201100077
(2011)Doi:10.1016/j.ejmech.2011.03.068
(2011)