Piperidinyl thiazole isoxazolines: A new series of highly potent, slowly reversible FAAH inhibitors with analgesic properties

DOI: 10.1016/j.bmcl.2016.02.061

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2965 - 2973 (2016)

Update date:2022-07-29

Topics:

Authors:

Pember, Stephen O.

Mejia, Galo L.

Price, Theodore J.

Pasteris, Robert J.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/j.bmcl.2016.02.061

Fatty acid amide hydrolase (FAAH) is a membrane anchored serine hydrolase that has a principle role in the metabolism of the endogenous cannabinoid anandamide. Docking studies using representative FAAH crystal structures revealed that compounds containing

Full text of DOI:10.1016/j.bmcl.2016.02.061

Products guided by the article

Product name:phenyl 4-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]-1-piperidinecarboxylate

Cas No:1310410-01-5

R&D Labs maybe for 1310410-01-5

Changzhou LanXu Chemical Co.,ltd.(expird)

Contact:86-0519-86330911,13656129734,15261186386

Address:Room 524, Depart.Chemical, Changzhou Science and Eductaion town, Jiangsu, China;Factory: Haian Fine Chemical Industry Park,Nantong,Jiangsu,China
Hebei Think-Do Environment Co., Ltd

website:http://www.thinkdo-environment.com

Contact:0311-86510809

Address:No 6, Shilian Middle Street, Circular Chemical Industry Park
xuri chemicals co., ltd

Contact:86-516-66656369

Address:The west road of Huaihai, Xuzhou, China
LIDE PHARMACEUTICALS LIMITED

website:http://www.lidepharma.com

Contact:+86-25-58409506

Address:11F, Building A1, No.288 North Zhongshan Road, Gulou District, Nanjing,210003, P.R.China.
WUXI KINGHAN BIO-MEDICAL&CHEMICAL INC.

Contact:13861062998

Address:Room 1316,No.1619 Huishan Avenue,Wuxi,China

Relevant to this article

Synthesis of sweet-tasting methylthio derivatives of D-fructose and sucrose.

Doi:10.1016/0008-6215(90)80126-N
(1990)
Hexulose derivatives and lipase-mediated diastereomeric resolution in the enantiospecific total synthesis of (-)-talaromycins C and E

Doi:10.1002/1099-0690(20021)2002:2<309::AID-EJOC309>3.0.CO;2-V
(2002)
Synthesis and crystal structure of hydrate adduct of 6-benzylaminopurine and 5-sulfosalicylic acid [(C₁₂H₁₂N₅)(C ₇H₅O₆S).H₂O]

Doi:10.1007/s10870-010-9709-7
(2010)
Nickel-catalyzed synthesis of 1,3,5-trisubstituted hydantoins from acrylates and isocyanates

Doi:10.1021/ol200957y
(2011)
Stereoselective Synthesis of (+/-)-cis-Inos-1,3-diamines

Doi:10.1039/P19900002255
(1990)
Design, synthesis, and validation of a β-turn mimetic library targeting protein - Protein and peptide - Receptor interactions

Doi:10.1021/ja201878v
(2011)

Article Doi