4β-[(4-Alkyl)-1,2,3-triazol-1-yl] podophyllotoxins as anticancer compounds: Design, synthesis and biological evaluation

DOI: 10.1016/j.ejmech.2011.02.016

Source and publish data:

European Journal of Medicinal Chemistry p. 1983 - 1991 (2011)

Update date:2022-08-02

Topics:

Authors:

Reddy, Doma Mahendhar

Srinivas, Jada

Chashoo, Gousia

Saxena, Ajit K.

Sampath Kumar

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Article abstract of DOI:10.1016/j.ejmech.2011.02.016

A series of 4β-[(4-alkyl)-1,2,3-triazol-1-yl] podophyllotoxin derivatives were designed in silico, synthesised by employing click chemistry approach, and evaluated for cytotoxicity against a panel of human cancer cell lines (SF-295, A-549, PC-3, Hep-2, HC

Full text of DOI:10.1016/j.ejmech.2011.02.016

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