Synthesis of amino 1,3-diols. Ring opening of N-acyl activated lactams with carbon nucleophiles

Article abstract of DOI:10.1080/00397919308013294

A synthesis of 6-amino-7-cyclohexyl-3,5-heptanediol 1 (CDH) and related amino 1,3-diols involving a nucleophilic ring opening of N-acyl activated lactams is described. Stereochemical proof of the 1,3-diol moiety is also presented.

Full text of DOI:10.1080/00397919308013294

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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Synthesis of Amino 1,3-
Diols. Ring Opening of N-Acyl
Activated Lactams with Carbon
Nucleophiles
S. Klutchko a , J. M. Hamby a , M. Reily a , M. D.
Taylor a & J. C. Hodges a
a Parke-Davis Pharmaceutical Research Division
Warner-Lambert Company , Ann Arbor, Michigan,
48105
Published online: 23 Sep 2006.
To cite this article: S. Klutchko , J. M. Hamby , M. Reily , M. D. Taylor & J. C. Hodges
(1993) Synthesis of Amino 1,3-Diols. Ring Opening of N-Acyl Activated Lactams
with Carbon Nucleophiles, Synthetic Communications: An International Journal
for Rapid Communication of Synthetic Organic Chemistry, 23:7, 971-983, DOI:
10.1080/00397919308013294
To link to this article: http://dx.doi.org/10.1080/00397919308013294
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