Organic Letters
Letter
(8) Zhao, D.; Kim, J. H.; Stegemann, L.; Strassert, C. A.; Glorius, F.
Angew. Chem., Int. Ed. 2015, 54, 4508.
(9) Wang, F.; Wang, H.; Wang, Q.; Yu, S.; Li, X. Org. Lett. 2016, 18,
3-ones, which are an important class of heterocyclic compounds
in medicinal chemistry.
1306.
ASSOCIATED CONTENT
* Supporting Information
■
(10) Hummel, J. R.; Ellman, J. A. J. Am. Chem. Soc. 2015, 137, 490.
(11) For recent reviews on ketenimines, see: (a) Wang, Y.; Lu, P.
Synlett 2010, 2010, 165. (b) Kim, S. H.; Park, S. H.; Choi, J. H.;
Chang, S. Chem. - Asian J. 2011, 6, 2618. (c) Lu, P.; Wang, Y. Chem.
Soc. Rev. 2012, 41, 5687. (d) Alajarin, M.; Marin-Luna, M.; Vidal, A.
Eur. J. Org. Chem. 2012, 2012, 5637.
(12) (a) Siuta, G. P.; Franck, R. W.; Kempton, R. P. J. Org. Chem.
1974, 39, 3739. (b) Galm, U.; Hager, M. H.; Van Lanen, S. G.; Ju, J.;
Thorson, J. S.; Shen, B. Chem. Rev. 2005, 105, 739. (c) Guillaumel, J.;
S
The Supporting Information is available free of charge on the
Detailed synthetic procedures and characterization data
Crystallographic information for compound 3a (CIF)
Crystallographic information for compound 5a (CIF)
Crystallographic information for compound 6a (CIF)
́ ́
Leonce, S.; Pierre, A.; Renard, P.; Pfeiffer, B.; Arimondo, P. B.;
Monneret, C. Eur. J. Med. Chem. 2006, 41, 379. (d) Elmegeed, G. A.;
Baiuomy, A. R.; Abdel-Salam, O. M. E. Eur. J. Med. Chem. 2007, 42,
1285. (e) Nirogi, R. V.; Kambhampati, R.; Kothmirkar, P.; Konda, J.;
Bandyala, T. R.; Gudla, P.; Arepalli, S.; Gangadasari, N. P.; Shinde, A.
K.; Deshpande, A. D.; Dwarampudi, A.; Chindhe, A. K.; Dubey, P. K. J.
Enzyme Inhib. Med. Chem. 2012, 27, 443.
AUTHOR INFORMATION
Corresponding Authors
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Notes
(13) McNab, H.; Tyas, R. G. J. Org. Chem. 2007, 72, 8760.
(14) Loffler, J.; Schobert, R. J. Chem. Soc., Perkin Trans. 1 1996, 2799.
̈
(15) Kandukuri, S. R.; Schiffner, J. A.; Oestreich, M. Angew. Chem.,
Int. Ed. 2012, 51, 1265.
The authors declare no competing financial interest.
(16) Yokoyama, Y.; Unoh, Y.; Bohmann, R. A.; Satoh, T.; Hirano, K.;
Bolm, C.; Miura, M. Chem. Lett. 2015, 44, 1104.
ACKNOWLEDGMENTS
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(17) For ORTEPs of products 3a, 5a, and 6a see the Supporting
Information. CCDC 1491448 (3a), 1491447 (5a), and 1491449 (6a)
contain supplementary crystallographic data for this paper. These data
can be obtained free of charge from the Cambridge Crystallographic
We thank the National Natural Science Foundation of China
(Nos. 21272204, 21272203 and J1210042) for financial
support.
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