Psoralenquinones as a novel class of proteasome inhibitors: Design, synthesis and biological evaluation

Article abstract of DOI:10.1002/cmdc.201100041

Proteasome subunit specificity: Psoralenquinones were identified as a novel class of nonpeptide proteasome inhibitors. Depending on the scaffold decoration, these compounds demonstrate interesting subunit specificity. Interactions with Thr1, Thr21 and Ser129 are critical for inhibition.