Nucleoside 3'-N,N-dialkylphosphonamidates: Novel building blocks for oligonucleotide synthesis

DOI: 10.1016/S0040-4039(00)97065-5

Source and publish data:

Tetrahedron Letters p. 6363 - 6366 (1990)

Update date:2022-08-03

Topics:

Authors:

Wada Wada

Ishikawa

Hata Hata

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Article abstract of DOI:10.1016/S0040-4039(00)97065-5

Nucleoside 3'-N,N-diisopropylphosphonamidates reacted with tris(2,4,6-tribromophenoxy)dichlorophosphorane (BDCP) to generate the corresponding aminophosphorochloridites without cleavage of the P-N bond. The reaction was applied to internucleotidic bond formation.

Full text of DOI:10.1016/S0040-4039(00)97065-5

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Product name:5'-O-(4,4'-dimethoxytrityl)-N³-benzoylthymidine 3'-N,N-diisopropylphosphonoamidate

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