The Asymmetric Addition of the Sn(II) Enolates of Thioesters to α-Iminoesters. A Convenient Synthesis of Optically Active cis-Substituted β-Lactams.

DOI: 10.1246/cl.1987.293

Source and publish data:

Chemistry Letters p. 293 - 296 (1987)

Update date:2022-08-05

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Authors:

Yamada, Tohru

Suzuki, Hiroshi

Mukaiyama, Teruaki

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Article abstract of DOI:10.1246/cl.1987.293

The asymmetric addition of the Sn(II) enolates derived from thioesters to α-iminoesters having the chiral auxiliary on the nitrogen atom proceeds smoothly to afford syn-β-aminoacid derivatives, which are in turn converted to optically active cis-substituted β-lactams.

Full text of DOI:10.1246/cl.1987.293

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