Tetrahedron Letters p. 6497 - 6500 (1990)
Update date:2022-08-04
Topics:
Cushman, Mark
Nagarathnam, Dhanapalan
A general method for the facile synthesis of ring-A hydroxylated flavones is described.Treatment of the hydroxylated acetophenones 6a-d with enough lithium bis(trimethyl)silyl amide to deprotonate all of the phenols as well as to generate the lithium enolate of the ketone, followed by addition of the acid chlorides 7a-d, gave the 1,3-diketones 8a-g, which were cyclized to the desired products 9a-g in high yields.
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