HYDROXY-(METHYLBUTENYNYL)-BENZOIC ACID AND DERIVATIVES FROM CURVULARIA FALLAX

Article abstract of DOI:10.1016/0031-9422(90)85203-R

4-Hydroxy-3-(3'-methyl-2'-butenyl)-benzoic acid, 4-hydroxy-3-(3'-methyl-3'-buten-1'-inyl)-benzoic acid, 2-isopropenylbenzofuran-5-carboxylic acid, anofinic acid and its 3,4-trans-dihydroxy derivative were isolated from the fungus Curvularia fallax.Biotransformation with p-amino-benzoic acid led to the corresponding 3-prenylbenzoic acid while 2,4-dihydroxybenzoic acid was alkylated in 5-position.Other related substrates were not prenylated by the microorganism.The biosynthesis of these compounds in C. fallax and Streptomyces niveus is compared.