The asymmetric synthesis of α-chloro α-alkyl and α-methyl α-alkyl phosphonic acids of high enantiomeric purity

Article abstract of DOI:10.1016/S0040-4039(00)97091-6

A method is described for the synthesis of α-chloro-α-alkyl- and α-methyl-α-alkylphosphonic acids in either enantiomeric form and in high optical purity, based on the asymmetric alkylation of α-substituted bicyclic phosphonamides derived from a C₂