Synthesis and biochemical evaluation of baclofen analogues locked in the baclofen solid-state conformation

Article abstract of DOI:10.1021/jm00108a011

The synthesis of six close analogues of baclofen [3-(4-chlorophenyl)-4-aminobutyric acid] (BAC), a potent GABA(B) agonist, are reported. The compounds were designed starting from the structural informations contained in the solid state of BAC, regarded as