SYNTHESIS OF ENANTIOMERIC PURE INTERMEDIATE FOR THE LACTONE PORTION OF COMPACTIN AND MEVINOLIN.

DOI: 10.1016/S0040-4020(01)87907-2

Source and publish data:

Tetrahedron p. 7283 - 7288 (1990)

Update date:2022-07-29

Topics:

Authors:

Cardani, Silvia

Scolastico, Carlo

Villa, Roberto

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Article abstract of DOI:10.1016/S0040-4020(01)87907-2

A diastereo and enantioselective synthesis of compound 11, a potential useful intermediate for the lactone portion of mevinolin and compactin, was developed.Our strategy is based on the high stereoselective Michael addition of alkoxide to chiral norephedr

Full text of DOI:10.1016/S0040-4020(01)87907-2

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