Potential Anti-AIDS Drugs. Lipophilic, Adenosine Deaminase-Activated Prodrugs

DOI: 10.1021/jm00109a018

Source and publish data:

Journal of Medicinal Chemistry p. 1647 - 1655 (1991)

Update date:2022-08-04

Topics:

Authors:

Barchi, Joseph J.

Marquez, Victor E.

Driscoll, John S.

Ford, Harry

Mitsuya, Hiroaki

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00109a018

Selected acid-stable (2'-fluoro-2',3'-dideoxyarabinofuranosyl)adenine nucleosides containing methyl groups and other lipophilic functions at various positions in the adenine ring were prepared and evaluated as anti-HIV agents.The N⁶-methyl (1f)

Full text of DOI:10.1021/jm00109a018

Products guided by the article

Product name:(2R,3R,4S,5R)-4-Fluoro-2-hydroxymethyl-5-purin-7-yl-tetrahydro-furan-3-ol

Cas No:132723-16-1

R&D Labs maybe for 132723-16-1

Afine Chemicals Limited

website:http://www.afinechem.com

Contact:+86-571-85134551

Address:No. 206 Zhen Hua Road, Hangzhou 310030, Zhejiang, China
Nanjing Chemzam Pharmtech Co., Ltd.

Contact:+86-25-86462165,+86-13915979898

Address:C5-1，6 Maiyue Road，Maigaoqiao，Nanjing，Jiangsu，China
YanCheng LongShen Chemical Co.,Ltd.

Contact:+86-515-86668866

Address:No.13,Weiyi Road,Funing Aoyang Industrial Park
Qingdao XinYongAn Chemicals Co., Ltd

Contact:+86-532-81107967

Address:Chengyang dual-port industrial park by the sea，Qingdao
Shanghai Mintchem Development ., Ltd

Contact:0086 21 5190 8570

Address:R602,4#,89Nong, Mudan Road Pudong Shanghai China

Relevant to this article

Design, Synthesis, and Biological Evaluation of a New Series of Carvedilol Derivatives That Protect Sensory Hair Cells from Aminoglycoside-Induced Damage by Blocking the Mechanoelectrical Transducer Channel

Doi:10.1021/acs.jmedchem.8b01325
(2019)
Dry reaction of indoles with carbonyl compounds on montmorillonite K10 clay: A mild, expedient synthesis of diindolylalkanes and vibrindole A

Doi:10.1016/S0040-4039(02)00682-2
(2002)
Doi:10.1039/jr9640005443
(1964)
Spectroscopic and computational studies of a Ni⁺-CO model complex: Implications for the acetyl-CoA synthase catalytic mechanism

Doi:10.1021/ic020441e
(2003)
The photochromic, electrochemical and third-order nonlinear optical properties of the novel naphthopyran derivatives

Doi:10.1016/j.dyepig.2020.108689
(2020)
Synthesis of (+/-)-puraquinonic acid: an inducer of cell differentiation.

Doi:10.1021/jo001523s
(2001)

Article Doi