Bioorganic and Medicinal Chemistry Letters p. 4056 - 4060 (2017)
Update date:2022-08-05
Topics:
Wang, Cailan
Corte, James R.
Rossi, Karen A.
Bozarth, Jeffrey M.
Wu, Yiming
Sheriff, Steven
Myers, Joseph E.
Luettgen, Joseph M.
Seiffert, Dietmar A.
Wexler, Ruth R.
Quan, Mimi L.
A series of macrocyclic factor XIa (FXIa) inhibitors was designed based on an analysis of the crystal structures of the acyclic phenylimidazole compounds. Further optimization using structure-based design led to inhibitors with pM affinity for FXIa, excellent selectivity against a panel of relevant serine proteases, and good potency in the activated partial thromboplastin time (aPTT) clotting assay.
View MoreContact:+86-22-26358246
Address:601-4-20, Fujiayuan, Tiantai Road, Hebei District, Tianjin, China
Contact:86-25-58619180
Address:Nanjing High-Tech Zone 10 Xinghuo Road Pukou District Nanjing, Jiangsu 210061 The People's Republic of China
Contact:86-21-58226973
Address:No 351,Guoshoujing Road, Zhangjiang Hi-tech Park, Pudong, Shanghai, China
Zhengzhou Xinlian Chemical Tech Co. ,Ltd
Contact:0371-65771781 021-52042910
Address:H Part, Building I, No. 700 Gonglu Road, Pudong New Area, Shanghai
Shanghai Hanshare Industry Co.,Ltd.
Contact:86 21 20960688
Address:RM902-903,Building E, Wanda Plaza,No.26,Zhoukang Road, Pudong District, Shanghai, China
Doi:10.1039/c2cc30776f
(2012)Doi:10.1002/cmdc.201100334
(2011)Doi:10.1021/jo200685e
(2011)Doi:10.1016/S0040-4039(00)01939-0
(2001)Doi:10.1246/cl.2012.920
(2012)Doi:10.1016/S0040-4020(00)01131-5
(2001)