Tetrahedron Letters p. 6907 - 6910 (1990)
Update date:2022-08-03
Topics:
Cragg, John E.
Herbert, Richard B.
Kgaphola, Mashupye M.
Diamines (6)-(8) and (11) act as acceptable substrates for diamine oxidase (DAO) and the novel phenacyl derivatives (2) are obtained in satisfactory preparative yield; no enantioselectivity is observed with (11) as an enzyme substrate.Remarkably, the triamines (9) and (13) are not oxidized and, moreover, (9) acts as a notable inhibitor for the DAO catalysed oxidation of (4) and (5).Kinetic evidence relevant to the mechanism of DAO action is presented, and is discussed in terms of a model for DAO-catalysed oxidation.
View Morewebsite:http://www.lonwinchem.com
Contact:Tel: 86-21-59858395
Address:No#966,Huaxu Road,Shanghai 201702,P.R.China
Contact:+86-20-32051076
Address:1105,Building A, International Business Incubator,Science City
qingdao goldenchem imp and exp co.,ltd.
Contact:532-55579246
Address:no.62 ,haier road laoshan distirct
Hebei Fulong Import & Export Co., Ltd.
Contact:86-311-87795661
Address:15A19 Zhongyuan Building,368 Youyi North Street,Shijiazhuang 050070,China
VanderArk International Limited
Contact:86-10-82437576
Address:Qing He
Doi:10.1016/S0040-4039(01)84211-8
(1966)Doi:10.1002/ejoc.201801222
(2018)Doi:10.1002/anie.201203723
(2012)Doi:10.1021/ol302607y
(2012)Doi:10.1016/j.bmcl.2017.03.027
(2017)Doi:10.1016/j.bmcl.2012.06.102
(2012)
