10.1002/anie.201801300
Angewandte Chemie International Edition
COMMUNICATION
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In summary, we report
a
new class of chiral 1,3,2-
diazaphospholenes that catalyze enantioselective 1,4-reduction
of α,β-unsaturated carbonyl compounds. These findings
underscore the large untapped potential of diazaphospholenes
as new axis of phosphorous-based organo-catalysts. Further
improvement and applications of these chiral hydride transfer
agents in other enantioselective transformations is currently
ongoing in our laboratory.
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This work is supported by Swiss National Science Foundation
(No 155967 and 175507). We thank Dr. R. Scopelliti and Dr. F.
Fadaei Tirani for X-ray analysis of P17.
Keywords: 1,3,2-diazaphospholenes • phosphorus •
asymmetric catalysis • 1,4-reduction • chiral hydride
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