Synthesis of Analogues of Iboga Alkaloids. Investigation of Electrophlic, Palladium-Catalyzed, and Radical Cyclizations for the Preparation of 5,6-Homoiboga Derivatives

Article abstract of DOI:10.1021/jo00311a022

The Diels-Alder adducts formed from 1-(benzyloxycarbonyl)-1,2-dihydropyridine or 1-(benzyloxycarbonyl)-4-methoxy-1,2-dihydropyridine by reaction with methyl 2-<1-(phenylsulfonyl)-1H-indol-2-yl>-2-propenoate can serve as precursors of the 5,6-homologues of