Resveratrol-maltol hybrids as multi-target-directed agents for Alzheimer's disease

Article abstract of DOI:10.1016/j.bmc.2018.08.011

The 3-hydroxypyran-4-one moiety (maltol) was incorporated into the structure of resveratrol to achieve a series of resveratrol-maltol hybrids (8a–8k) as novel multi-target-directed ligands (MTDLs). In vitro biological evaluation of the MTDLs revealed these compounds to have a triple function, namely inhibition of self-induced Aβ_1–42 aggregation, antioxidation, and metal chelating activity. Among all the evaluated MTDLs, compounds 8i and 8j showed the most promise, demonstrating micromolar IC₅₀ values for Aβ_1–42 aggregation inhibition, more potent ABTS^[rad]+ scavenging activity than Trolox, and good metal chelating activities.

Full text of DOI:10.1016/j.bmc.2018.08.011

Accepted Manuscript
Resveratrol-Maltol Hybrids as Multi-Target-Directed Agents for Alzheimer’s
Disease
Gang Cheng, Ping Xu, Minkui Zhang, Jing Chen, Rong Sheng, Yongmin Ma
PII:
S0968-0896(18)31089-7
https://doi.org/10.1016/j.bmc.2018.08.011
BMC 14498
DOI:
Reference:
Bioorganic & Medicinal Chemistry
To appear in:
Received Date:
Revised Date:
Accepted Date:
10 June 2018
29 July 2018
7 August 2018
Please cite this article as: Cheng, G., Xu, P., Zhang, M., Chen, J., Sheng, R., Ma, Y., Resveratrol-Maltol Hybrids
as Multi-Target-Directed Agents for Alzheimer’s Disease, Bioorganic & Medicinal Chemistry (2018), doi: https://
doi.org/10.1016/j.bmc.2018.08.011
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