3-[[(Aryloxy)alkyl]piperidinyl]-1,2-benzisoxazoles as D2/5-HT2 antagonists with potential atypical antipsychotic activity: Antipsychotic profile of iloperidone (HP 873)

DOI: 10.1021/jm00007a009

Source and publish data:

Journal of Medicinal Chemistry p. 1119 - 1131 (1995)

Update date:2022-07-29

Topics: Antipsychotic

Authors:

Strupczewski

Bordeau Bordeau

Chiang Chiang

Glamkowski

Conway Conway

Corbett Corbett

Hartman Hartman

Szewczak

Wilmot Wilmot

Helsley Helsley

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00007a009

A series of 3-[[(aryloxy)alkyl]piperidinyl]-1,2-benzisoxazoles was synthesized and evaluated as potential antipsychotic D₂/5-HT₂ antagonists. Most of these compounds showed potent antipsychotic-like activity in an apomorphine-induced

Full text of DOI:10.1021/jm00007a009

Products guided by the article

Product name:4-(3-bromopropoxy)-3-methoxybenzamide

Cas No:133455-22-8

R&D Labs maybe for 133455-22-8

Xi'an caijing Opto-Electrical Science & Technology Co., LTD

Contact:+86-29-88294447

Address:NO.168 Zhangba Rd. East, Xi'an, P.R.China
Jiangsu Institute of Ecomones Co., Ltd

website:http://www.jsmone.com

Contact:+86-519-82821700

Address:95 Huanyuan N. Road, Jintan, Jiangsu, China
HANGZHOU TOYOND BIOTECH CO., LTD

Contact:+86-571-86965177

Address:No. 189, Fengqi East Road, Hangzhou, China
TIANJIN NORTH JINHENG CHEMICAL PLANT.

Contact:0086-22-59952083

Address:DongShigu Country In JiXian TianJin China
Wuhan Shengmao Corp

website:http://www.shengmaochem.com

Contact:86-27-82853423, 82819281

Address:Rm 202, A Unit Huaqiao Building No. 2, Lihuangpi Road, Wuhan, China

Relevant to this article

Synthesis, photochemistry, and photophysics of butadiene derivatives: Influence of the methyl group on the molecular structure and photoinduced behavior

Doi:10.1021/jo200691x
(2011)
Anthraceno-perylene bisimides: The precursor of a new acene

Doi:10.1021/ol202417u
(2011)
High efficient and high color pure blue light emitting materials: New asymmetrically highly twisted host and guest based on anthracene

Doi:10.1016/j.dyepig.2011.06.008
(2012)
New Synthesis and Diels-Alder Reactions of 2-Aminomethyl-1,3-butadienes and Related 1,3-Dienes

Doi:10.1246/bcsj.64.1051
(1991)
Catalytic Halogen Bond Activation in the Benzylic C-H Bond Iodination with Iodohydantoins

Doi:10.1021/acs.orglett.7b03034
(2017)
Tandem MS analysis of selenamide-derivatized peptide ions

Doi:10.1007/s13361-011-0170-4
(2011)

Article Doi