3-[[(Aryloxy)alkyl]piperidinyl]-1,2-benzisoxazoles as D2/5-HT2 antagonists with potential atypical antipsychotic activity: Antipsychotic profile of iloperidone (HP 873)

DOI: 10.1021/jm00007a009

Source and publish data:

Journal of Medicinal Chemistry p. 1119 - 1131 (1995)

Update date:2022-07-29

Topics: Antipsychotic

Authors:

Strupczewski

Bordeau Bordeau

Chiang Chiang

Glamkowski

Conway Conway

Corbett Corbett

Hartman Hartman

Szewczak

Wilmot Wilmot

Helsley Helsley

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Article abstract of DOI:10.1021/jm00007a009

A series of 3-[[(aryloxy)alkyl]piperidinyl]-1,2-benzisoxazoles was synthesized and evaluated as potential antipsychotic D₂/5-HT₂ antagonists. Most of these compounds showed potent antipsychotic-like activity in an apomorphine-induced

Full text of DOI:10.1021/jm00007a009

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