3-[[(Aryloxy)alkyl]piperidinyl]-1,2-benzisoxazoles as D2/5-HT2 antagonists with potential atypical antipsychotic activity: Antipsychotic profile of iloperidone (HP 873)

Article abstract of DOI:10.1021/jm00007a009

A series of 3-[[(aryloxy)alkyl]piperidinyl]-1,2-benzisoxazoles was synthesized and evaluated as potential antipsychotic D₂/5-HT₂ antagonists. Most of these compounds showed potent antipsychotic-like activity in an apomorphine-induced