Synthetic approaches to the guanosine and xanthosine analogues 5-amino-3-β-D-ribofuranosylpyrazolo[3,4-e][1,3]oxazin-7-one and 3-β-D-ribofuranosylpyrazolo[3,4-e][1,3]oxazine-5,7-dione and studies of their antitumor potential

Article abstract of DOI:10.1021/jm00111a005

5-Amino-3-β-D-ribofuranosylpyrazolo[3,4-e][1,3]oxazin-7-one has been synthesized via cyclization of the appropriately protected pyrazofurin derivatives and subsequent transformations of the hetorocyclic moiety. This guanosine analogue was marginally cytot