Verapamil analogues with restricted molecular flexibility

DOI: 10.1021/jm00111a043

Source and publish data:

Journal of Medicinal Chemistry p. 2219 - 2225 (1991)

Update date:2022-08-03

Topics:

Authors:

Dei Dei

Romanelli

Scapecchi

Teodori Teodori

Chiarini

Gualtieri

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Article abstract of DOI:10.1021/jm00111a043

Three analogues with restricted flexibility were designed to study the active conformation of verapamil during interaction with the slow calcium channel. Thus cis- and trans-1-(3,4-dimethoxyphenyl)-4-[N-[2-(3,4-dimethoxyphenyl)ethyl]-N-me thylamino]-r-1-c

Full text of DOI:10.1021/jm00111a043

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