ENZYMATIC RESOLUTION OF AN ARYLPIPERIDINE DERIVATIVE UTILIZING LIPASE CATALYZED HYDROLYSIS

DOI: 10.1016/S0957-4166(00)80543-1

Source and publish data:

Tetrahedron Asymmetry p. 535 - 536 (1990)

Update date:2022-09-26

Topics:

Authors:

Nieduzak, Thaddeus R.

Carr, Albert A.

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Article abstract of DOI:10.1016/S0957-4166(00)80543-1

Enantiospecific hydrolysis of the acetate 1 was carried out on a multigram scale utilizing a lipase from Aspergillus niger.Both stereoisomers R-(+) and S-(-) were obtained with high enantiomeric purity (>97 percent ee).

Full text of DOI:10.1016/S0957-4166(00)80543-1

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