Synthetic studies on (+)-hydantocidin (1): A total synthesis of (+)-hydantocidin, a new herbicidal metabolite from microorganism

Article abstract of DOI:10.1016/S0040-4020(01)96122-8

A total synthesis of (+)-hydantocidin 1, a new class of ribofuranose derivative exhibiting herbicidal activity, is reported. The spiro-hydantoin ring at the anomeric position of D-ribofuranose was constructed from substituted hydantoin derivatives 6, 7, and 12 through acid and base-promoted cyclization methods.