Synthesis p. 207 - 209 (1991)
Update date:2022-07-30
Topics:
Gorbunova
Gerus
Galushko
Kukhar
The 4,4,4-trifluoro-3-oxo-1-butenyl group is proposed as a suitable protecting group for the protection of the N-H terminal of amino acids in peptide synthesis. Amino acids react with 4-ethoxy-1,1,1-trifluoro-3-buten-2-one to give the N-protected amino acids, the protecting group can be removed by acidic hydrolysis. The formation of peptide bonds using on N-4,4,4-trifluoro-3-oxo-1-butenyl protected amino acids occurs without racemization.
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Doi:10.1016/0022-328X(91)83118-N
(1991)Doi:10.1248/cpb.43.1148
(1995)Doi:10.1021/acs.joc.8b00486
(2018)Doi:10.1080/00397919108020799
(1991)Doi:10.1016/j.bmcl.2011.08.117
(2011)Doi:10.1016/j.tet.2015.05.045
(2015)