Highly Efficient Synthesis of 13-Dehydroprostaglandins by 1,4-Addition Reaction of Alkynyl ω Side-Chain Unit onto Cyclopentenone Framework

Article abstract of DOI:10.1021/jo00010a004

Optically active 2-((diethylamino)methyl)-4-siloxy-2-cyclopentenone (2) reacts with a diethyl(3-(tert-butyldimethylsiloxy)-1-alkynyl)aluminum compound via 1,4-addition pathway to afford the enone 5, useful intermediate for synthesis of PGs via two-component coupling process, in excellent yield, thus making it easy to synthesize 13-dehydro-PGs.